Vanderbilt University - Deparment of Biomedical Engineering
The dataset includes data from structural, resting-tate, and field maps images from 21 non-human primates.
Usage Agreement
Custom Data Usage Agreement (DUA) - Users must complete a data usage agreement (DUA) prior to gaining access to the data.
Species
Macaca Mulatta
Sample Description
- Sample size: 21
- Age distribution: 2-30 years old
- Weight distribution: 5-10 kg
- Sex distribution: 10 female
Click here for the full sample description (.csv)
Phenotypic Assessments
Scan Procedures and Parameters
Ethics approval: All procedures were conducted in compliance with State and Federal laws, standards of the US Department of Health and Human Services, and guidelines established by the Wake Forest University Health Sciences Institutional Animal Care and Use Committee as well as the National Institute of Health Guide for the Care and Use of Laboratory Animals (A20-079; A18-037).
Scanning preparations
Anesthesia procedures: In preparation for the MRI scan, anesthesia was induced using ketamine (5–10mg/kg), dexmedetomidine (0.015mg/kg) and was maintained using isoflurane. The animals were intubated and artificially ventilated at 95–120 breath per minute. Expired CO2 was monitored and maintained between 35 and 45 mmHg. Animals were scanned under isoflurane anaesthesia at 1&percent;–1.5&percent;. Heart rate and oxygen saturation levels were monitored using a pulseoximeter. Body temperature was maintained using warm blankets.
Time between anesthesia and scanning: 1 hour between ketamine induction and isoflurane
Head fixation: None
Position in scanner and procedure used: lying on their back
Contrast agent: None
During scanning
Physiological monitoring: The animals were intubated and artificially ventilated at 95–120 breaths per minute. Expired CO2 was monitored and maintained between 35 and 45 mmHg.
Scan sequences
Scanner type:Siemens MAGNETOM Skyra 3T
MRI parameters: adult head coil
| Voxel resolution (mm) | TR (ms) | TE (ms) | Inversion time (ms) | FOV | Flip angle | Number of slices | Phase encoding direction | |
|---|---|---|---|---|---|---|---|---|
| T1w | 0.5 x 0.5 | 2700 | 3.39 | 880 | 128 x 128 | 192 | ||
| T2w | 0.5 x 0.5 | 3200 | 235 | 128 x 128 | 160 | |||
| Resting-state | 2 x 2 | 700 | 32 | 32 x 32 | 52° | 32 | A >> P | |
| Field map | 2 x 2 | 700 | 32 | 32 x 32 | 52° | 32 | P >> A |
MRI parameters: pediatric head coil
| Voxel resolution (mm) | TR (ms) | TE (ms) | Inversion time (ms) | FOV | Flip angle | Number of slices | Phase encoding direction | |
|---|---|---|---|---|---|---|---|---|
| T1w | 0.5 x 0.5 | 2700 | 3.32 | 880 | 128 x 128 | 192 | ||
| T2w | 0.5 x 0.5 | 3200 | 344 | 128 x 128 | 160 | |||
| Resting-state | 2 x 2 | 700 | 32 | 32 x 32 | 52° | 32 | A >> P | |
| Field map | 2 x 2 | 700 | 32 | 32 x 32 | 52° | 32 | P >> A |
Publications
- Garin CM, Hori Y, Everling S, Whitlow CT, Calabro FJ, Luna B, et al. An evolutionary gap in primate default mode network organization. Cell reports. 2022;39(2):110669.
Personnel
- Clement M. Garin1,2,3,4
- Yuki Hori5
- Stefan Everling5,6
- Christopher T. Whitlow7
- Finnegan J. Calabro8,9
- Beatriz Luna8
- Mathilda Froesel10
- Maeva Gacoin10
- Suliann Ben Hamed10
- Marc Dhenain3,4
- Christos Constantinidis1,11
1Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA
2Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
3Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, 92265 Fontenay-aux-Roses, France
4Université Paris-Saclay, CEA, Molecular Imaging Research Center, 92265 Fontenay-aux-Roses, France
5Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London, ONN6A 5B7, Canada
6Department of Physiology and Pharmacology, The University of Western Ontario, London, ON N6A 5C1, Canada
7Department of Radiology, Section of Neuroradiology, Wake Forest School of Medicine, Winston-Salem, NC, USA
8Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
9Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
10Institut des Sciences Cognitives Marc Jeannerod, UMR5229 CNRS Université de Lyon, 67 Boulevard Pinel, 69675 Bron Cedex, France
11Neuroscience Program, Vanderbilt University, Nashville, TN 37235, USA 12Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Acknowledgements
We wish to thank Gracie Hilber, Connor Hebert, Austin Lodish, Junda Zhu, Lena Marie Moretz, and Stephanie Rideout for their outstanding assistance in the experiments.
Funding
This work was supported by the National Institute of Mental Health of the National Institutes of Health under award numbers R01 MH116675 and R01 MH117996.
Downloads
The data for this site are password protected. Please complete the data usage agreement and submit to CMIDataUsage@childmind.org for access to the dataset.
Click here to download the encrypted data. Users will first be prompted to log on to NITRC and will need to register with the 1000 Functional Connectomes Project website on NITRC to gain access to the PRIME-DE datasets.